Via car or truck, Waterbury is within 120 minutes of major distribution markets throughout the Northeast – including Connecticut, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania and Vermont.

The City is 21 miles north of New Haven, 29 miles southwest of Hartford, and 24 miles east of Danbury. To the east of Waterbury, I-84 provides direct access to Hartford and joins the Massachusetts Turnpike for travel to Boston and northern New England. Heading west, I-84 passes through Danbury and crosses the states of New York and Pennsylvania, with connections to the New York Thruway and Interstate 80. Route 8 south meets the Connecticut Turnpike (I-95) in Bridgeport, making all of southern Connecticut and Fairfield County easily accessible. To the north, Route 8 ultimately leads through Torrington to the Massachusetts Turnpike.